INTERGENERATIONAL EFFECTS OF PRECONCEPTION OPIOIDS ON GLUCOSE HOMEOSTASIS AND HEPATIC TRANSCRIPTION IN ADULT MALE RATS

Intergenerational effects of preconception opioids on glucose homeostasis and hepatic transcription in adult male rats

Abstract Adolescence represents a period of significant neurodevelopment during which adverse experiences can lead to prolonged effects on disease vulnerability, including effects that can impact future offspring.Adolescence is a common period for the initiation of drug use, including the use of opioids.Beyond effects on central reward, opioids als

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THE IMPACT OF ECONOMIC, POLITICAL, AND INSTITUTIONAL FACTORS ON BUDGET BALANCES OF THE HEAVILY INDEBTED EUROPEAN COUNTRIES

The present study identifies socioeconomic, political, and institutional factors that shape extensive budget unbalances in four European Mediterranean countries (Portugal, Italy, Greece, and Spain), causing significant deficits and a public debt equal to (or above) 120% of their respective Gross Domestic Product at the read more end of 2020.The reg

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THE IMPACT OF ECONOMIC, POLITICAL, AND INSTITUTIONAL FACTORS ON BUDGET BALANCES OF THE HEAVILY INDEBTED EUROPEAN COUNTRIES

The present study identifies socioeconomic, political, and institutional factors that shape extensive budget unbalances in four European Mediterranean countries (Portugal, Italy, Greece, and Spain), causing significant deficits and a public debt equal to (or above) 120% of their respective Gross Domestic Product at the read more end of 2020.The reg

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The Emerging Role of Nanomedicine in the Management of Nonalcoholic Fatty Liver Disease: A State-of-the-Art Review

Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease that can lead to end-stage liver disease needing a liver transplant.Many pharmacological approaches are used to reduce the disease progression in NAFLD.However, current strategies remain ineffective to reverse the progression of NAFLD completely.Employing nanoparticles as a

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